Mutant THC Receptors Predispose to Migraine

A recent (2009) scientific publication from a lab in the UK has established a link between migraines and mutations in the Cannabinoid Type 1 receptor (CB1R aka The”Pot receptor”). Researchers extracted DNA from individuals who were surveyed and reported suffering from migraines. The researchers found the 1st direct evidence that an isoform or mutant form of CB1R can make you susceptible to migraines.

Previous studies have shown that the natural THC our body makes, anandamide, has migraine preventative actions (on the trigeminal nerve). CB1R antagonists (things that block the receptor) reverse this protective effect. Thus, there is significant data suggesting that the CB1R is involved with migraines.

Interestingly, the International Headache Society has yet to classify or identify any migraine-related genes despite intense research into the subject.

Disclaimer: This article is intended for informational purposes only and does not constitute medical advice. Always consult a healthcare professional for medical diagnosis or treatment recommendations.